
What the day-after ache is actually signaling
The soreness after a long effort is not the same signal as chronic inflammation, and muscle IL-6 is not a fire alarm.
Marco Elling
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The soreness after a long effort is not the same signal as chronic inflammation, and muscle IL-6 is not a fire alarm.

The mid-afternoon slump is circadian and post-meal, with mitochondria supplying ATP at the pace the cell allows.

Dopamine in hard effort is a keep-going signal, not a pleasure spray that arrives when the work is over.

A short night raises the morning cortisol signal and makes the same breakfast harder for insulin to clear.